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Metabolic syndrome,代谢综合征
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特色产品

1. 代谢综合征简介

2. PCSK9 ELISA and PCSK9-LDLR in vitro Binding Assay Kits

3. Adipokine/Lipid metabolism ELISA Kits

4. Glycated Proteins/AGEs related Kits

5. S100 Protein family ELISA Kits

6. Inflammation/Other marker



代谢综合征简介


代谢综合征的特点是因肥胖而导致一系列代谢危险因素聚集在个人身上,这些因素包括高血脂,高血压,糖尿病等。患有代谢综合征的人群在患有动脉硬化,胰岛素抵抗和氧化应激疾病的几率大大增加。

MBL的子公司CycLex推出的CircuLex系列产品,是用于心血管疾病药物开发的优秀产品,包括定量检测试剂盒以及相关抗体等。



PCSK9 ELISA and PCSK9-LDLR in vitro Binding Assay Kits


PCSK9(Proprotein convertase subtilisin kexin 9)/NARC-1(Neural apoptosis-regulated convertase) 是丝氨酸蛋白酶的一种,主要在肝脏,肾脏及小肠中表达量较多。与低密度蛋白LDL受体相结合,起到加速降解LDL受体的作用。

近年发现,抑制素等胆固醇生物合成抑制剂的治疗药的投入可导致血清中PCSK9 mRNA的表达水平明显增高。经研究证实在服用高胆固醇血症治疗药的同时如果能阻碍LDL受体与PCSK9相结合,或抑制PCSK9水平增加的话,就可以仅仅使用低浓度药物而达到很好的药效。前PCSK9作为一个新的治疗靶点已成为高胆固醇血症研究的热点, 对于深入了解胆固醇代谢的机制和寻求新的治疗手段有重要意义。


PCSK9 Kit列表:

货号

产品名称

规格

CY-8079

CircuLex Human  PCSK9 ELISA Kit

96 assays

CY-8078

CircuLex Mouse/Rat  PCSK9 ELISA Kit

96 assays

CY-8150

CircuLex PCSK9-LDLR  in vitro Binding Assay Kit

96 assays

CY-R2310

PCSK9 Wild Type in  culture medium

50 ug

CY-R2311

PCSK9 D374Y in  culture medium

50 ug

CY-R2320

PCSK9 Wild Type/Δ53 in culture medium

20 ug

CY-R2321

PCSK9 D374Y/Δ53 in culture medium

10 ug

CY-R2330

PCSK9 Wild Type  (Human)

50 ug

CY-R2331

PCSK9 D374Y

10 ug

CY-R2333

PCSK9 R194A

20 ug


References:

  • Cariou B, Langhi C, Le Bras M, Bortolotti M, Lê KA, Theytaz F, Le May C, Guyomarc'h-Delasalle B, Zaïr Y, Kreis R, Boesch C, Krempf M, Tappy L, Costet P. Plasma PCSK9 concentrations during an oral fat load and after short term high-fat, high-fat high-protein and high-fructose diets. Nutr Metab. 10:4. 2013(PMID:23298392)

  • Jamie Cameron, Martin P. Bogsrud, Kristian Tveten, Thea Bismo Str_m, Kirsten Holven, Knut Erik Berge, Trond P. Leren; Serum levels of proprotein convertase subtilisin/kexin type 9 in subjects with familial hypercholesterolemia indicate that proprotein convertase subtilisin/kexin type 9 is cleared from plasma by low-density lipoprotein receptor_independent pathways. Translational Research. 160: 125-30. 2012(PMID:22683370)

  • Roeland Huijgen, Sigrid W. Fouchier, Michael Denoun, Barbara A. Hutten, Maud N. Vissers, Gilles Lambert and John J. P. Kastelein; Plasma levels of proprotein convertase subtilisin Kexin type 9 (PCSK9) and phenotypic variability in familial hypercholesterolemia. J Lipid Res. 53: 979-83. 2012(PMID:22375030)


Adipokine/Lipid metabolism ELISA Kits


Adipokine/Lipid metabolism ELISA Kits 产品列表:

货号

产品名称

规格

CY-8050

CircuLex Human  Adiponectin ELISA Kit

96 assays

CY-8049

CircuLex Rat  Adiponectin ELISA Kit

96 assays

CY-8051

CircuLex Mouse  Adiponectin ELISA Kit

96 assays

CY-8052

CircuLex Dog  Adiponectin ELISA Kit

96 assays

CY-8076

CircuLex Rat  FABP4/A-FABP ELISA Kit

96 assays

CY-8077

CircuLex Mouse  FABP4/A-FABP ELISA Kit

96 assays

CY-8072

CircuLex Human RBP4  ELISA Kit

96 assays

CY-8065

CircuLex Mouse  Visfatin/PBEF ELISA Kit

96 assays

CY-8075

CircuLex Mouse  AIM/CD5L/Spα ELISA  kit

96 assays

CY-8080

CircuLex Human  AIM/CD5L/Spα ELISA  kit

96 assays

CY-8054

CircuLex Mouse  FABP1/L-FABP ELISA Kit

96 assays

CY-8055

CircuLex Mouse  FABP3/H-FABP ELISA Kit

96 assays

CY-8056

CircuLex Mouse  FABP5/E-FABP/mal1 ELISA Kit

96 assays



Glycated Proteins/AGEs related Kits


Glycated Proteins/AGEs related Kits 产品列表:

货号

产品名称

规格

CY-8066

CircuLex CML/Nε  -(Carboxymethyl)lysine ELISA Kit

96 assays

CY-8083

CircuLex Human  sRAGE ELISA Kit

96 assays

CY-8151

CircuLex AGE-RAGE  in vitro Binding Assay Kit

96 assays

CY-8067

CircuLex Anti-CML  mouse autoantibody ELISA Kit

96 assays

CY-8068

CircuLex Anti-CML  human autoantibody ELISA Kit

96 assays

CY-8069

CircuLex Anti-CML  rat autoantibody ELISA Kit

96 assays



S100 Protein family ELISA Kits


S100 Protein family ELISA Kits 产品列表:

货号

产品名称

规格

CY-8057

CircuLex S100A13  ELISA Kit

96 assays

CY-8058

CircuLex  S100A12/EN-RAGE ELISA Kit

96 assays

CY-8060

CircuLex S100P  ELISA Kit

96 assays

CY-8061

CircuLex  S100A8/MRP8 ELISA Kit

96 assays

CY-8062

CircuLex  S100A9/MRP14 ELISA Kit

96 assays

CY-8063

CircuLex S100A11  ELISA Kit

96 assays

CY-8064

CircuLex S100A14  ELISA Kit

96 assays

CY-8073

CircuLex S100A7/Psoriasin  ELISA Kit

96 assays

CY-8086

CircuLex S100A4  ELISA Kit Ver.2

96 assays

CY-8095

CircuLex S100A10  ELISA Kit

96 assays

CY-8097

CircuLex S100A6  ELISA Kit

96 Assays



Inflammation/Other marker


Inflammation/Other marker 产品列表:

货号

产品名称

规格

CY-8090

CircuLex Human  TXNIP ELISA Kit

96 assays

CY-8089

CircuLex Human  Lactoferrin ELISA Kit

96 assays

CY-8087

CircuLex Human  YKL-39 ELISA Kit

96 assays

CY-8088

CircuLex Human  YKL-40 ELISA Kit

96 assays

CY-1248

CycLex Acidic  Mammalian Chitinase Fluorometric Assay Kit

100 assays

CY-1249

CycLex  Chitotriosidase Fluorometric Assay Kit

100 assays

CY-8074

CircuLex Human  Chitotriosidase ELISA Kit

96 assays

CY-8082

CircuLex 14-3-3  Gamma ELISA Kit

96 assays

CY-8085

CircuLex Human  ISG15 ELISA Kit

96 assays

CY-8091

CircuLex Mouse  ISG15 ELISA Kit

96 assays

CY-8092

CircuLex Human  UCHL1 ELISA Kit

96 assays

CY-8093

CircuLex Mouse  UCHL1 ELISA Kit

96 assays

CY-8071

CircuLex  High-Sensitivity CRP ELISA Kit

96 assays

CY-9050

CircuLex DJ-1/PARK7  ELISA Kit

96 assays

CY-8053

CircuLex Rat  NGAL/Lipocalin-2 ELISA Kit

96 assays

CY-8070

CircuLex Human  NGAL/Lipocalin-2 ELISA Kit

96 assays

CY-8084

CircuLex Human AIF1  ELISA Kit

96 assays